Memory gains seen in twin trial

A twin trial shows daily protein plus a prebiotic mix improves memory in healthy older adults over 12 weeks.

Gut friendly supplement boosts memory in older adults

In a double blind randomized study, 36 pairs of twins aged 60 or older were assigned one twin to receive inulin plus fructooligosaccharides and the other a placebo, alongside identical branched chain amino acid protein powder and home-based strength moves. The trial ran remotely over 12 weeks, with online cognitive tests and stool samples to track gut microbes. The twin design helps separate genetic and early environmental influences from the supplement effect.

Results showed the prebiotic-protein group scored higher on a composite memory measure and made fewer errors on the PAL test, a task that probes episodic memory. Gut microbes shifted toward Bifidobacterium, and adherence was high with only mild gastrointestinal complaints. Muscle strength did not improve, suggesting cognitive gains may come independently of physical changes.

The study adds to a growing body of work linking the gut and the brain, showing that a simple, accessible intervention can move a cognitive needle in healthy aging. Remote trial design also demonstrates that rigorous science can be conducted without forcing older adults to travel.

But the work has limits. The sample is modest and mostly female, so we cannot assume the same results for all older adults or those with dementia. More research is needed to see if these gains persist at 6 to 12 months and whether they translate into real-life improvements in daily functioning.

Highlights

Ongoing research will show how long any cognitive benefits last and who is most likely to benefit.