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New study uncovers genetic factors in chronic fatigue syndrome

Large-scale research identifies key genetic regions that may influence ME/CFS development.

August 6, 2025 at 06:01 PM
blur Scientists find link between genes and ME/chronic fatigue syndrome

Researchers unveil significant genetic factors linked to chronic fatigue syndrome.

Genetics play a role in developing chronic fatigue syndrome

A significant study has revealed a genetic connection to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This research, involving over 27,000 affected individuals and a control group of 250,000, identified eight areas in the human genome associated with ME/CFS. These areas contain genes related to immune function and the nervous system. The findings indicate that while specific genetic variants may increase the risk of developing ME/CFS, many carriers of these variants may not develop the illness. This discovery is being hailed as a potential breakthrough for understanding and treating the condition.

Key Takeaways

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Recent study links genetics to ME/CFS risk.
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Eight genomic regions significantly different in affected individuals were identified.
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This research adds credibility to the understanding of ME/CFS as a legitimate illness.
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Many patients feel abandoned by the medical system.
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Further studies are needed to explore diagnostics and treatment options.
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The study may help combat stigma and change funding perspectives for ME/CFS research.

"These provide the first robust evidence for genetic contributions to ME."

Prof Chris Ponting discusses the importance of the genetic evidence in understanding ME/CFS.

"This will be huge for the patient population."

Andy Devereux-Cooke highlights the impact of the findings on those affected by ME/CFS.

"It's a very sad fact that people with ME/CFS are still disbelieved."

Dr Beata Godlewska reflects on the stigma surrounding ME/CFS and the need for research support.

The implications of these findings extend beyond genetics. For decades, ME/CFS has faced stigma and neglect, yet this research challenges long-standing dismissal of the illness. By providing a robust genetic basis, the study aims to shift perceptions, validating the experiences of millions worldwide. As researchers explore further, there remains a critical need for effective diagnostics and treatments, especially considering the extensive economic burden of the condition.

Highlights

  • Genetics could tip the balance for ME/CFS development.
  • This research shines a light on a long-neglected illness.
  • ME/CFS is not just in the mind; it's biological.
  • These findings provide much-needed validation for patients.

Potential stigma and funding challenges

While research highlights genetic links to ME/CFS, the stigma around the illness persists. This can hinder funding and support for affected individuals.

Future research must build on these findings to improve patient outcomes.

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