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New diet may help protect semaglutide users from muscle loss
Protein-rich foods could mitigate muscle loss linked to semaglutide use, say researchers.

Scientists highlight how protein intake can mitigate muscle loss from weight-loss drugs.
Seven protein-rich foods can prevent muscle loss in those using semaglutide
Women and older adults using the weight-loss drug semaglutide may protect themselves from muscle loss by increasing protein intake, according to new research. A study presented at the ENDO 2025 conference indicates that those taking semaglutide are at risk of losing muscle mass, which can negatively affect metabolism and bone health. The research, involving 40 adults with obesity, shows that while those on semaglutide lost more weight, they experienced a similar percentage of lean mass loss compared to individuals on a lifestyle-based weight-loss program. Dr. Melanie Haines, the lead researcher, notes that older age, female gender, and low protein consumption are linked to greater muscle loss, which can hinder blood sugar control.
Key Takeaways
"Older adults and women may be more likely to lose muscle on semaglutide, but eating more protein may help protect against this."
Dr. Melanie Haines emphasizes the need for protein in mitigating muscle loss among certain groups.
"Losing too much muscle may reduce the benefits of semaglutide on blood sugar control."
Dr. Haines warns about the negative impact of muscle loss on metabolic health.
This focus on protein intake finds its roots in the growing concern for the health of older adults and women who are prescribed semaglutide. By highlighting specific dietary adjustments, researchers like Dr. Haines are not just addressing a side effect but also advocating for a holistic approach in health management. The potential to preserve muscle may reinforce the benefits of weight loss in managing health outcomes, particularly in populations likely to struggle with obesity-related diseases. As semaglutide continues to gain popularity, nutrition's role in its use will likely draw more attention.
Highlights
- Protein may hold the key to preserving muscle while using semaglutide.
- For older adults, protecting muscle health is vital during weight loss.
- Increasing protein intake can change the weight loss game for many.
- Semaglutide users should consider their diet as seriously as their medication.
Concerns Over Muscle Loss During Weight Loss Treatment
The study highlights a potential risk for muscle loss among patients using semaglutide, particularly in vulnerable groups such as older adults and women. Nutritional adjustments are recommended to balance these risks, raising implications for public health messaging.
As the landscape of weight-loss solutions evolves, dietary considerations will be crucial for effective health outcomes.
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