Gabapentin for back pain linked to dementia risk

The use of gabapentin for chronic back pain is facing scrutiny due to its potential effects on brain health.

Common drug for back pain linked to increased dementia risk

Chronic back pain affects many individuals, leading to missed work and diminished quality of life. Gabapentin, an anticonvulsant typically prescribed for seizures and nerve pain, is often used off-label for treating this type of pain. A recent study published in 2025 in Regional Anesthesia and Pain Medicine reveals concerning findings. It indicates that individuals using gabapentin for back pain face a 29% higher risk of developing dementia compared to those not taking the drug. This risk increases to a staggering 85% for mild cognitive impairment. Notably, younger adults, particularly those under 65, exhibit double the risk of dementia when using gabapentin. Those with higher prescription counts also show elevated risks, suggesting long-term use may contribute to cognitive decline.

The implications of this research are significant. As gabapentin becomes a more common choice for managing chronic back pain, healthcare providers must carefully weigh the risks and benefits. The potential link between gabapentin and dementia raises essential questions about patient safety and treatment guidelines. Patients dealing with chronic pain are often desperate for relief, which may lead them to overlook potential cognitive risks. Understanding these risks is crucial for informed decision-making and could prompt urgent revisions to prescribing practices or alternative treatments.

Highlights

As research continues, patients and doctors must engage in discussions about medication safety and alternatives.