COVID-19 Linked to Alzheimer’s-Like Changes

A new study suggests COVID-19 may lead to Alzheimer’s-like protein build-up in both brain and eyes.

COVID-19 Linked to Alzheimer's-Like Changes in Eyes and Brain

Recent research from Yale University reveals that COVID-19 may cause protein accumulation similar to changes found in Alzheimer's patients, particularly affecting the brain and eyes. This study aims to understand the relationship between symptoms like 'brain fog' and Alzheimer's-like plaques. The researchers found amyloid beta, a protein linked to Alzheimer's, in the retinas and brains of individuals who had COVID-19. Elevated levels of this protein were noted even in those without dementia histories after COVID-19 infection. By using retinal tissue and organoids, they discovered that the virus's spike protein could induce amyloid beta accumulation. They also identified NRP1 as a potential target that, when inhibited, might reduce this protein's build-up, opening up new avenues for treatment and understanding of neurological complications from COVID-19.

This study highlights a concerning development in our understanding of COVID-19's long-term effects. The research establishes a clear link between the virus and neurological changes, suggesting that COVID-19 could potentially exacerbate or even induce conditions similar to Alzheimer's disease. The identification of NRP1 as a molecular target for treatment opens up fascinating possibilities for future research. As scientists delve deeper into this connection, implications for public health and future treatment frameworks may become clearer, prompting urgent attention toward post-COVID neurological health.

Highlights

This research may reshape how we view COVID-19's impact on long-term neurological health.