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Colorectal cancer rises in younger adults as screening guidelines expand

New ACS findings link earlier screening to more early-stage detections in adults 45 to 49, with equity gaps still to address.

August 8, 2025 at 12:22 PM
blur Colorectal cancer diagnoses soar among younger adults for one key reason

Updated screening guidance lowers the starting age and is linked to more early detections in adults aged 45 to 49.

Colorectal cancer rises in younger adults as screening guidelines expand

New ACS studies show more colorectal cancer diagnoses among adults aged 45 to 49 after earlier screening guidance. In a JAMA analysis, local-stage cancers increased in this age group from 2019 to 2022, with a 50 percent rise from 2021 to 2022. The ACS lowered the recommended screening age from 50 to 45 in 2018, and the USPSTF followed in 2021. A second ACS study reports CRC screening in 45 to 49 rose 62 percent from 2019 to 2023; colonoscopy increased 43 percent and stool-based tests rose more than fivefold.

Key Takeaways

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Screening uptake in 45 to 49 rose 62% from 2019 to 2023
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Local-stage colon cancer detection rose about 19% each year for those in their late 40s
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Colonoscopy screening in 45 to 49 rose 43%
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Stool-based testing in 45 to 49 rose more than fivefold
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Screening completion increased from 20% in 2021 to 37% in 2023 for 45 to 49
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Equity gaps persist by education and insurance status in screening
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Early detection improves five year survival rates and reduces late stage cases

"It is thrilling to see this increase in screening among younger individuals"

Star notes enthusiasm about higher screening rates in 45 to 49

"This study reinforces the need to focus research on causes behind rising colon cancer in younger adults"

Oberstein advocates for more research on causes of increases

"Early detection is crucial because survival improves when cancer is found early"

Comment on the survival benefits of early detection

"The rise in diagnoses for those in their 40s is an alarming reminder that screening must be easier and more accessible to reach the unscreened"

Eagle highlights access issues amid rising cases

This is a policy driven medical trend. Expanding screening has real life value, but it also exposes who gets tested and who does not. Equity in access to screening must be part of the plan so that gains are not wasted on people with already good health coverage.

If the trend continues, the conversation will shift from whether screening is needed to how to fund and deliver it in a way that reaches all communities. The health system will face questions about insurance, education, and how to reach people who are not currently enrolled. The long term impact could be lower late stage disease and higher cure rates if the rollout is inclusive and practical.

Highlights

  • Early screening saves lives when it reaches those who need it most
  • Equity in access to screening is the real test
  • Screening expansion is a start not a finish
  • Catching cancer early shifts the odds toward cure

Policy and access risks linked to younger screening

The discussion around earlier screening touches policy, funding, and equity. If not handled well, it could spark political backlash or uneven access.

As screening guidelines evolve, the focus turns to making testing accessible for every adult who could benefit.

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