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New study suggests mastectomy could prevent thousands of breast cancer cases

A study shows that more women may benefit from preventive mastectomy to reduce cancer risk.

July 24, 2025 at 05:50 PM
blur Thousands of cancer cases could be prevented with more breast removal surgeries, study suggests

A recent study suggests that increased breast removal surgeries might prevent many cancer cases.

Study finds more breast removal surgeries could prevent thousands of cancer cases

A new study indicates that thousands of breast cancer cases could be avoided if preventive mastectomy were more widely offered. Research suggests that about 6,500 cases could be averted each year in the UK alone if women at high risk, particularly those with certain genetic markers, were given the option of risk-reducing mastectomies. Currently, these surgeries are primarily available to women with BRCA1, BRCA2, and PALB2 genes. However, the study suggests other gene mutations like ATM, CHEK2, RAD51C, and RAD51D may also warrant consideration for mastectomy if combined with other risk factors like family history and mammogram density. The cost-effectiveness of this approach has been backed by an economic evaluation from Queen Mary University of London and LSHTM, leading researchers to push for expanded access to such surgeries.

Key Takeaways

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About 6,500 breast cancer cases could be prevented annually in the UK.
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Current options are limited to specific genetic markers for mastectomy.
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The study addresses additional genes that may indicate risk for breast cancer.
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Economic analysis supports the cost-effectiveness of preventive mastectomy.
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Individualized care is crucial for women considering surgery.
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Awareness of all risk management options is essential for informed choices.

"Our results could have significant clinical implications to expand access to mastectomy beyond those patients with known genetic susceptibility."

Professor Ranjit Manchanda highlights the broader impact of the research findings.

"Choosing to have risk-reducing surgery is a complex and deeply personal decision that comes with emotional and physical implications."

Louise Grimsdell emphasizes the importance of informed consent and emotional support in decision-making.

This study highlights an important shift in how breast cancer risks are evaluated and managed. It opens a door for many women who may have previously felt unprotected under traditional guidelines. Yet, while extending surgical options could lead to significant reductions in cancer cases, it brings complex emotional and medical implications. Women must be fully informed of all available options, including non-surgical alternatives. This calls for a more nuanced approach within the healthcare system, ensuring that patients receive comprehensive support as they navigate these life-altering decisions.

Highlights

  • More options mean more lives saved.
  • Risk-reducing surgery is a personal journey.
  • Understanding all options is crucial for women.
  • Cancer prevention demands innovative pathways.

Potential Risk of Controversy with Expanding Mastectomy Options

Offering preventive mastectomies could face backlash regarding informed consent and emotional implications for patients.

As awareness grows, healthcare systems must adapt to offer comprehensive support.

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