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Greg Iles dies at 65

Mississippi author behind the Natchez Burning trilogy has died after a long battle with multiple myeloma; his final novel Southern Man was published in 2024.

August 17, 2025 at 05:46 AM
blur Greg Iles, Mississippi author of ‘Natchez Burning’ trilogy, dies of cancer at 65

Greg Iles, the Mississippi author behind the Natchez Burning trilogy, has died after a long battle with multiple myeloma.

Greg Iles dies at 65

Greg Iles, the Mississippi author behind the Natchez Burning trilogy, died Friday at age 65 after a decades long battle with multiple myeloma. Born in Germany and raised in Natchez, he built a career around stories rooted in Mississippi and its fraught history of race and class. His final novel, Southern Man, was published in 2024, the same year he disclosed his illness.

Key Takeaways

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Iles tied his fiction closely to Mississippi and its complex history
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Southern Man appeared in 2024 amid his health battle
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He worked with The Rock Bottom Remainders alongside famous authors
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His illness and late publishing year shape his literary legacy
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His work fights tough questions about race in the Jim Crow era
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The loss underscores the enduring appeal of regionally grounded thrillers
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He was described as warm, funny, fearless, and sui generis

"warm, funny, fearless, and completely sui generis."

Agent Dan Conaway describing Iles

"To be on the other end of the phone as he talked through character and plot, problem solving on the fly, was to witness genius at work."

Conaway on Iles' creative process

"fused story-craft, bone-deep humanity, and a growing sense of moral and political responsibility"

Conaway on Iles' writing approach

"Initially diagnosed with the incurable condition in 1996, he kept his illness private"

Health timeline mentioned in the report

Iles is best known for novels that blend suspense with a careful look at Mississippi's past. His work uses intimate relationships to illuminate larger social forces, and critics often praised his balance of fast pacing with moral questions. This approach helped bring regional stories to a national audience and sparked conversations about how history is told in thrillers.

Highlights

  • Mississippi voices find a stubbornly cinematic form
  • A life spent listening to the quiet courage of ordinary people
  • His books ask hard questions and keep readers turning pages
  • Writers can share a stage with stars and still tell tough truths

Racial history and political sensitivities in regional fiction

The article touches on race and class in the Jim Crow era, which can provoke debates and backlash. Care should be taken not to sensationalize sensitive topics and to respect regional histories.

The region will remember him through its stories.

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